Department of Biochemistry
415 South St
Waltham, MA 02454
The lab, with the lovely historic Brandeis Usen Castle in background, August 2, 2013.
Left to right: Rick Roy, Erin Devine, Brian Beckett, Joe Jacobowitz, Kristine Mackin, Jeff Boucher, Phil Steindel, Douglas Theobald.
Kristine Mackin, PhD
Kristine just successfully defended her PhD, March 20, 2014 — Congrats Dr Mackin!
Kristine's thesis project explored the biophysical constraints on the evolution of bacteriorhodopsin and the implications for convergence of the GPCR protein fold in rhodopsins from bacteria, arachaea, and eumetazoans.
Phillip Steindel, PhD
Phil successfully defended his PhD, September 23, 2013 — Congrats Dr Steindel!
Phillip Steindel was a graduate student in the Biophysics and Structural Biology program.
He has a BS in Chemistry from UNC-Chapel Hill.
Phil is developing Bayesian and likelihood methods for analyzing macromolecular structures, in addition to the evolution of substrate specificity in parabasalid malate and lactate dehydrogenases.
Brian C. Beckett
Brian graduated from McGill in 2012 with a M.Sc. in Structural Cell Biology and in 2010 with a B.Sc. in Anatomy and Cell Biology, and Theater.
He is pursuing a Ph.D. in Biochemistry and Biophysics, and is studying protein evolution and the dynamics of strong evolutionary epistasis.
He is passionate about conquering scientific apathy, the education of young scientists, and donuts.
Find out more about Brian.
Erin studies the evolution of visual cone opsins in metazoans.
She's also interested in the physical constraints on rhodopsin and GPCR structure and evolution, and the implications for discerning homology from convergence.
Rick works on understanding the functional and structural constraints on universally conserved residues in Type I rhodopsins.
Jacob is interested in the evolution of allostery and other cryptic long-range interactions in proteins.
Michelle Y. Fry (2015)
Michelle is making a constitutive dimer from tetrameric Apicomplexan lactate dehydrogenases.
Joe Jacobowitz (2014)
Joe is figuring out how Plasmodium falsciparum lactate dehydrogenase has such strong specificity for its substrate.
He's good at crystallizing proteins, especially ancestral 2-hydroxyacid dehydrogenases.
Jeff Boucher, PhD
Jeff also holds a BS in Biochemistry from Worcester Polytechnic Institute, and he was a graduate student in the Biochemistry program here at Brandeis.
In his former life, Jeff spent over four years slaving for biotechnology companies in the Boston area, including Pierce Biotechnology, Phylogix, and Epitome Biosystems.
Jeff's PhD thesis research investigated the evolution of substrate specificity in apicomplexan malate and lactate dehydrogenases.
Mackenzie Gallegos, Research Technician (Brandeis 2011)
Mackenzie kept the world turning :(.
Adam Drake, undergraduate student (2013)
Adam's thesis research developed better phylogenetic methods for modeling the evolution of transmembrane proteins by explicitly incorporating structural information.
He graduated in 2013 with an MS/BS in Biochemistry, highest honors.
Adam is now spending the summer of 2013 in the Adirondack woods.
Emily Chen, undergraduate student (2013)
Emily helped determine the crystal structures of both ancestral and modern malate/lactate dehydrogenases.
Amy Eisenberg, undergraduate student (2012)
Amy's senior thesis was on the physical requirements on the position and identity of the conserved "counterion" aspartate residue in bacteriorhodopsin, including its evolutionary implications.
Megan Peck, High school student
Marcus Kelly, undergraduate student (2011)
While in the lab, Mark's senior thesis involved the development of membrane protein specific substitution matrices for modeling transmembrane proteins.
Mark is currently a graduate student at Stanford.
Nathaniel Lazar, undergraduate student (2010)
During his tenure in the lab, Nat's thesis research involved developing structural methods for analyzing and determining rates of evolution specific to particular protein families.
Nat is currently a graduate student at Cornell.
Bojan Rajkovic, undergraduate student (2010)
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M. Viera, Research Assistant
Marco was the lab's Research Assistant from 2007 to 2010. Marco used to keep the world turning.
Marion Estelle Peyrega, French high school student
What is Marion doing now?
Hannah Kirsch, undergraduate student (2010)